Evaluation of Bleeding Following Dental Extraction in Patients Undergoing Single or Dual Antiplatelet Therapy – A Prospective Randomized Controlled Study.

Abstract

Background & Aim- Bleeding complications after dental extraction are a concern for patients on antiplatelet therapy, which prevents clot formation but increases bleeding risk. While discontinuing aspirin before surgery may not be necessary, evidence on managing dual or non-aspirin antiplatelet users is limited. This study evaluates the impact of single and dual antiplatelet drugs on post-extraction bleeding.

Materials & Methods- This prospective randomized study, conducted from January 2019 to January 2023, included 80 patients divided into single and dual antiplatelet therapy groups. All extractions were performed in the mandible to control local hemostatic effects. Blood loss was measured using pre-weighed gauze, with post-operative bleeding assessed every 30 minutes for two hours.

Result- The study found no significant differences between the two groups in gender distribution, bleeding time, platelet count, tooth per unit area, or total blood loss during and after extraction. One-way ANOVA showed no significant variations in post-operative blood loss at different time intervals.

Conclusion- This study suggests that stopping dual antiplatelet therapy before dental extractions may not be necessary. Patients on aspirin, clopidogrel, or ticlopidine for over three months can safely undergo extractions without altering their regimen. Atraumatic techniques are recommended for intra-alveolar extractions.