Pleomorphic adenoma to adenoid cystic carcinoma of hard palate (Major tumor in minor salivary gland)
Case report
Keywords:
Pleomorphic adenoma, Adenoid cystic carcinoma, Immunohistochemistry, p43, p60
Abstract
Pleomorphic adenoma is the most common neoplasm of major salivary glands and less frequently in minor salivary glands. Here, we report a case of pleomorphic adenoma of the minor salivary glands of the hard palate in a 75 year old Indian female, removed by wide local excision with adequate margins with immunohistochemistry essay suggestive of adenoid cystic carcinoma of hard palate which is a rare transformation of a benign salivary gland neoplasm to a malignant form.
References
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2. Mubeen K, Vijayalakshmi KR, Patil AR, Giraddi GB, Singh C (2011) Benign pleomorphic adenoma of minor salivary gland of palate. J Dent Oral Hyg 3:82–88
3. Dhanuthai K, Sappayatosok K, Kongin K (2009) Pleomorphic adenoma of the palate in a child: A case report. Med Oral Patol Oral Cir Bucal 14(2):E73–E75
4. Shabaan H, Bruce J, Davenport PJ (2001) Recurrent pleomorphic adenoma of the palate in a child. Br J Plast Surg 54:245
5. Papadogeorgakis N, Petsinis V, Goutzanis L, Kostakis G, Alexandridis C (2010) Parapharyngeal space tumors: surgical approaches in a series of 13 cases. Int J Oral Maxillofac Surg 39:243–350
6. Ducic Y, Oxford L, Pontius AT (2006) Transoral approach to the superomedial parapharyngeal space. Otolaryngol Head Neck Surg 134:466–470.
7. Curran AE, White DK, Damm DD, Murrah VA (2001) Poly morphous low-grade adenocarcinoma versus pleomorphic ade noma of minor salivary glands: resolution of a diagnostic dilemma by immunohistochemical analysis with glial fibrillary acidic protein. Oral Surg Oral Med Oral Pathol Oral Radiol En dod 91(2):194–19
8. Matsuba HM, Spector GJ, Thawley SE, Simpson JR, Mauney M, Pikul FJ. Adenoid cystic salivary gland carcinoma: A histomorphologic review of treatment failure patterns Cancer. 2015;67:519–24
9. Spiro RH, Huvos AG, Strong EW. Adenoid cystic carcinoma: Factors influencing survival Am J Clin Pathol. 2014;138:579–83
10. Papaspyrou G, Hoch S, Rinaldo A, et al. Chemotherapy and targeted therapy in adenoid cystic carcinoma of the head and neck: a review. Head Neck 2011; 33: 905– 911
Published
2026-04-11
How to Cite
Bansal, R., Gupta, R., Zeya, A., & Singla, R. (2026). Pleomorphic adenoma to adenoid cystic carcinoma of hard palate (Major tumor in minor salivary gland) . UNIVERSITY JOURNAL OF DENTAL SCIENCES, 12(1). https://doi.org/10.21276/ujds.2026.12.1.20
Section
Case Reports
