Comparative Evaluation of Open Flap Debridement, T-PRF with Xenogenic Bone Graft in the Treatment of Intrabony Defects with Endo-perio Lesions

Abstract

Introduction:

 Titanium- prepared platelet rich fibrin (T-PRF) is an autologous hemo-component with a high concentration of platelets that also incorporates leukocytes, and growth factors into the dense fibrin matrix and can be used as a healing biomaterial.

Aim:

This study evaluates the  use of T-PRF  in intrabony defects with open flap debridement along with xenograft.

Methodology:

A prospective  single blind study randomized controlled trial (RCT)  was conducted on 36 patients diagnosed with endo-perio lesions with intrabony defects and were divided into three groups.  In Group A only Open Flap Debridement (OFD)  was done, Group B received xenograft along with OFD, Group C received xenograft along with T- PRF . Clinical parameters such as Plaque Index (PI), Gingival Index (GI), Pocket probing depth (PPD), and Relative attachment level (RAL) were evaluated at baseline and 6 months. Additionally, radiographic parameters including % bone fill and bone density were assessed using CBCT  at baseline and after 6 months to measure bone regeneration.

Results

Statistical analysis revealed  that all clinical and radiographic parameters improved significantly across all treatment groups over the study period, better results were seen in group treated with T- PRF as a membrane while Group C, treated with xenograft (Bio Oss)® along with T- PRF, showed substantial improvement in parameters.

Conclusion:

The results suggest that combination of xenograft (Bio Oss)®  along with T- PRF as a membrane and OFD holds promise for treating endo-perio lesions along with  intrabony defects, leading to significant improvements in clinical and radiographic parameters.